我也有一个类似的问题，我希望我的EC2（标准Amazon AMI）上的SQLite3 PHP支持，但是PHP与--without-sqlite3一起编译。
如何添加sqlite3支持？它的软件来自存储库，所以我不能仅重新运行./configure脚本
更多信息：
我尝试从pecl安装它而没有成功，而且它说该版本为 0.6 (alpha)，并且仅通过PECL简短地提供了SQLITE3支持，并且应将其编译到PHP可执行文件中（我认为）。它令人困惑。
我也有PDO扩展名（某些网站说SQLite3在PDO中）
这是我尝试使用PECL的方法：
ec2-user[~]> pecl search sqlite
Retrieving data...0%
..Matched packages, channel pecl.php.net:
=======================================
Package Stable/(Latest) Local
PDO_SQLITE 1.0.1 (stable) SQLite v3 Interface driver for PDO
SQLite 1.0.3 (stable) SQLite database bindings
sqlite3 0.6 (alpha) SQLite v3 Database Bindings.
ec2-user[~]> pecl download sqlite3
Failed to download pecl/sqlite3 within preferred state "stable", latest release is version 0.6, stability "alpha", use "channel://pecl.php.net/sqlite3-0.6" to install
download failed
ec2-user[~]> pecl download channel://pecl.php.net/sqlite3-0.6
downloading sqlite3-0.6.tgz ...
Starting to download sqlite3-0.6.tgz (768,302 bytes)
.........................................................................................................................................................done: 768,302 bytes
File /home/ec2-user/sqlite3-0.6.tgz downloaded
ec2-user[~]> sudo pecl install sqlite3-0.6.tgz
84 source files, building
running: phpize
Configuring for:
PHP Api Version: 20090626
Zend Module Api No: 20090626
Zend Extension Api No: 220090626
Optionally provide the path to the libsqlite3 library [autodetect] : yes
building in /var/tmp/pear-build-root8Jljf1/sqlite3-0.6
(...)
/var/tmp/sqlite3/sqlite3.c:1586: error: duplicate 'static' // repeated lots of times
make: *** [sqlite3.lo] Error 1
ERROR: `make' failed
编辑：没有php-sqlite或php5-sqlite软件包
ec2-user[~]> sudo yum search sqlite
Loaded plugins: fastestmirror, priorities, security, update-motd, upgrade-helper
Loading mirror speeds from cached hostfile
* amzn-main: packages.us-west-2.amazonaws.com
* amzn-updates: packages.us-west-2.amazonaws.com
========================================================================= N/S Matched: sqlite ==========================================================================
apr-util-sqlite.x86_64 : APR utility library SQLite DBD driver
libdbi-dbd-sqlite.x86_64 : SQLite plugin for libdbi
python-sqlite.x86_64 : Python bindings for sqlite.
python24-sqlite.x86_64 : Python bindings for sqlite.
sqlite-devel.x86_64 : Development tools for the sqlite3 embeddable SQL database engine
sqlite-doc.x86_64 : Documentation for sqlite
sqlite-tcl.x86_64 : Tcl module for the sqlite3 embeddable SQL database engine
perl-DBD-SQLite.x86_64 : Self Contained RDBMS in a DBI Driver
sqlite.i686 : Library that implements an embeddable SQL database engine
sqlite.x86_64 : Library that implements an embeddable SQL database engine
编辑2：在启用企业Linux（EPEL）存储库的（默认情况下）的额外软件包后，也没有上述软件包
我认为Amazon Ami现在对此问题还可以。我的默认php 5.4来自Repos的安装已启用了SQLite3支持。
[root@amazon-ami php.d]# php -m | grep sqlite
pdo_sqlite
sqlite3
[root@amazon-ami php.d]#
例如，此代码对我来说很好：
$db = new SQLite3('localDB.sqlite');
$db->exec('CREATE TABLE test (foo STRING)');
$db->exec("INSERT INTO test (foo) VALUES ('bar')");
$results = $db->query('SELECT foo FROM test');
while ($row = $results->fetchArray())
echo $row['foo'];
我最终为此放弃了EC2，并在VM中安置了Linux Mint。
如果有人知道解决方案，尽管我很乐意接受他的答案。
对于Amazon Linux上的sqlite，我做了以下操作：
sudo yum install sqlite-devel